Publications

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Merched A and Chan L (2013). Nutrigenetics and Genomics of Atherosclerosis. Current Atherosclerosis Reports 15(6):
328.
Merched AJ. Editorial. Inflammation in chronic and infectious diseases.
Clinica Chimica Acta. 2012;413(1-2).

Merched AJ, Serhan CN, Chan L. (2011). Nutrigenetic disruption of inflammation-resolution homeostasis and
atherogenesis.
J Nutrigenet Nutrigenomics. 2011;4(1):12-24.

Merched A, Tollefson K, and Chan L (2010). The dynamic involvement of b2 integrins in the initiation and the progression
of atherosclerosis in the LDLR knockout mouse model.
Cardiovascular Research 85(4):853-863.

Merched AJ, Ko K, Gotlinger K, Serhan CN and Chan L. (2008). Atherosclerosis: Evidence for impairment of resolution of
vascular inflammation governed by specific lipid mediators.
FASEB Journal; 22(10):3595-606.

Cheng J, Zhang J, Merched A, Zhang L, Zhang P, Truong L, Boriek AM and Du J. (2007). Mechanical stretch suppresses
Ox-LDL-induced apoptosis in vascular smooth muscle cells by upregulating integrin alpha vbeta 3 and stabilization of
PINCH-1.
J Biol Chem 282(47):34268-75.

Lau PP, Li L, Merched AJ, Zhang AL, Ko KWS and Chan L. (2006). Nicotine Induces Proinflammatory Responses in
Macrophages and the Aorta Leading to Acceleration of Atherosclerosis in LDLR-/- Mice.
Arteriosclerosis Thrombosis and
Vascular Biology
. 26(1):143-149

Merched A and Chan L. (2004). Absence of p21(Waf1/Cip1/Sdi1) Modulates Macrophage Differentiation and Inflammatory
Response and Protects Against Atherosclerosis.
Circulation. 110(25):3830-3841.

Nomura S, Merched A, Nour E, Dieker C, Oka K and Chan L. (2004). LDL Receptor gene therapy with helper-dependent
adenovirus produces long-term protection in a mouse model of  familial hypercholesterolemia.
Gene Therapy. 11(20):
1540-1548.

Serhan CN, Jain A, Marleau S, Clish C, Kantarci A, Behbehani B, Colgan SP, Stahl GL, Merched A, Petasis NA, Chan L,
and Van Dyke TE. (2003).Reduced inflammation and tissue damage in transgenic rabbits overexpressiong 15-
lipoxygenase and endogenous anti-inflammatory lipid mediators.
Journal of Immunology. 171: 6856-6865.

Merched A, Williams L and Chan L. (2003). Macrophage-specific p53 expression plays a crucial role in atherosclerosis
development and plaque remodeling.
Arteriosclerosis Thrombosis and Vascular Biology. 23(9):1608-14..

Belalcazar M*, Merched A*
, Carr B, Oka K, Chen K-H, Pastore L, Beaudet A, Chan L. Long-term stable expression of
human apolipoprotein A-I mediated by helper-dependent adenovirus gene transfer inhibits atherosclerosis progression
and remodels atherosclerotic plaques in a mouse model of familial hypercholesterolemia (* equal contribution).

Circulation
107:2726-2732.

Oka K, Pastore L, Kim I-H, Merched A, Nomura S, Lee HJ, Merched-Sauvage M, Arden-Riley C, Lee B, Finegold M, Beaudet
A, Chan L. Long-term reversal of hypercholesterolemia and prevention of atherosclerosis development in LDL receptor-
deficient mice by transfer of the VLDL receptor gene in vivo using helper-dependent adenoviral vector.
Circulation. 103(9):
1274-1281.

Merched A, Xia Y, Visvikis S, Serot JM, Siest G (2000). Decreases in high density lipoprotein- cholesterol and serum
apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer's disease.
Neurobiology of Aging;
2000;21(1):27-30.

Dergunov AD, Smirnova EA, Merched A, Visvikis S, Siest G (2000). Conformation of apolipoprotein E both in free and in
lipid-bound form may determine the avidity of triglyceride-rich lipoproteins to the LDL receptor: structural and kinetic study.
Biochimica Biophysica Acta/Molecular and Cell Biology of Lipids;1484(1):14-28.

Dergunov AD, Smirnova EA, Merched A, Visvikis S, Siest G (2000). Structural peculiarities of the binding of very low density
lipoproteins and low density lipoproteins to the LDL receptor in hypertriglyceridemia: role of apolipoprotein E.
Biochimica
Biophysica Acta
/Molecular and Cell Biology of Lipids;1484(1):29-40.

Merched A, Serot JM, Visvikis S, Faure G and Siest G (1998). Apolipoprotein E, Transthyretin and Actin in the CSF of
Alzheimer’s Patients: Relation with the Senile Plaques and Cytoskeleton Biochemistry.
FEBS Letters; 425(2):225-228.

Terrisse L., Poirier J, Bertrand Ph, Merched A, Siest G, Ross M, and Rassart E (1998). Increased levels of ApoD in
cerebrospinal fluid and hippocampus of Alzheimer's patients.
Journal of Neurochemistry; 71(4):1643-1650.

Merched A, Xia Y, Papadopoulou A, Siest G and Visvikis S. (1998 ) Apolipoprotein AIV codon 360 mutation increases with
aging and is not associated with Alzheimer’s disease.
Neuroscience Letters; 242(2):117-119.

Merched A., Blain H, Visvikis S., Herbeth B, Jeandel C, and Siest G. (1997) Cerebrospinal fluid Apolipoprotein E is
increased in late onset Alzheimer’s disease.
Journal of the Neurological Science; 145: 33-39.

Blain H, Merched A, Visvikis S, Siest G, and Jeandel C (1997) Apolipoprotein E level in cerebrospinal fluid increases with
aging.
Journal of the American Geriatric Society; 45(12):1536.

Book chapters
Merched A and Chan L. (2010). Atherosclerosis in experimental animal models. In: Serhan CN, Ward PA, Gilroy DW, eds.
Fundamentals of Inflammation. Cambridge University Press; 426-431.

Bohnet K., Schlenck A., Merched A., Siest G., Visvikis S. (1997) Apolipoprotein R136C. A rare variant of human
apolipoprotein E discovered during the STANISLAS Cohort study In: Biologie prospective. Comptes Rendus du 9°
Colloque de Pont à Mousson, Ed. Galteau MM, Delwaide P, Siest G, Henny J. John Libbey Eurotext, Paris, pp 167-170.

Merched A, L. Terrisse, P. Bertrand, J. Poirier, S. Visvikis, G. Siest, R. Milne, E. Rassart (1998) Les apolipoprotéines D et E
dans le système nerveux central des patients Alzheimeriens. In: Actualités sur la Maladie d’Alzheimer et les Syndromes
Apparentés Ed. Gelly-Nargeot MC, Ritchi K, Touchon J. SOLAL, Marseille, France, pp 57-63.

Merched A, S. Visvikis, J.-M. Serot, L. Terrisse, E. Rassart, G. Siest (1998). Génétique de l’apolipoprotéine E et Association
avec la transthyrétine, l’apolipoproteine D et l’actine dans la maladie d’Alzheimer. In: Actualités sur la Maladie d’Alzheimer
et les Syndromes Apparentés Ed. Gelly-Nargeot MC, Ritchi K, Touchon J. SOLAL, Marseille, France, pp 65-72.

Blain H, Merched A, Visvikis S, Herbeth B, Siest G and Jeandel C (1998). La concentration de l’apolipoprotéine E dans le
liquide céphalorchidien est augmentée dans le maladie d’Alzheimer. In: Actualités sur la Maladie d’Alzheimer et les
Syndromes Apparentés Ed. Gelly-Nargeot MC, Ritchi K, Touchon J. SOLAL, Marseille, France, pp 33-42.
Prof. Aksam J. Merched's Scientific Publications
Research interests:

Inflammation, innate immunity, autoimmunity, immunotherapy, phagocytosis, lipid biochemistry,
liver cancer, biomarkers, animal models, molecular nutrition, nutrigenetics of essential fatty
acids, lipid mediators, Alzheimer's disease, cardiovascular diseases,



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