Publications

Merched A and Chan L (2013). Nutrigenetics and Genomics of Atherosclerosis. Current Atherosclerosis Reports 15(6):328.
Merched AJ. Editorial. Inflammation in chronic and infectious diseases.
Clinica Chimica Acta. 2012;413(1-2).

Merched AJ, Serhan CN, Chan L. (2011). Nutrigenetic disruption of inflammation-resolution homeostasis and atherogenesis.
J
Nutrigenet Nutrigenomics.
2011;4(1):12-24.

Merched A, Tollefson K, and Chan L (2010). The dynamic involvement of b2 integrins in the initiation and the progression of
atherosclerosis in the LDLR knockout mouse model.
Cardiovascular Research 85(4):853-863.

Merched AJ, Ko K, Gotlinger K, Serhan CN and Chan L. (2008). Atherosclerosis: Evidence for impairment of resolution of vascular
inflammation governed by specific lipid mediators.
FASEB Journal; 22(10):3595-606.

Cheng J, Zhang J, Merched A, Zhang L, Zhang P, Truong L, Boriek AM and Du J. (2007). Mechanical stretch suppresses Ox-LDL-
induced apoptosis in vascular smooth muscle cells by upregulating integrin alpha vbeta 3 and stabilization of PINCH-1.
J Biol Chem
282(47):34268-75.

Lau PP, Li L, Merched AJ, Zhang AL, Ko KWS and Chan L. (2006). Nicotine Induces Proinflammatory Responses in Macrophages and
the Aorta Leading to Acceleration of Atherosclerosis in LDLR-/- Mice.
Arteriosclerosis Thrombosis and Vascular Biology. 26(1):143-
149

Merched A and Chan L. (2004). Absence of p21(Waf1/Cip1/Sdi1) Modulates Macrophage Differentiation and Inflammatory Response
and Protects Against Atherosclerosis.
Circulation. 110(25):3830-3841.

Nomura S, Merched A, Nour E, Dieker C, Oka K and Chan L. (2004). LDL Receptor gene therapy with helper-dependent adenovirus
produces long-term protection in a mouse model of  familial hypercholesterolemia.
Gene Therapy. 11(20):1540-1548.

Serhan CN, Jain A, Marleau S, Clish C, Kantarci A, Behbehani B, Colgan SP, Stahl GL, Merched A, Petasis NA, Chan L, and Van Dyke
TE. (2003).Reduced inflammation and tissue damage in transgenic rabbits overexpressiong 15-lipoxygenase and endogenous anti-
inflammatory lipid mediators.
Journal of Immunology. 171: 6856-6865.

Merched A, Williams L and Chan L. (2003). Macrophage-specific p53 expression plays a crucial role in atherosclerosis development
and plaque remodeling.
Arteriosclerosis Thrombosis and Vascular Biology. 23(9):1608-14..

Belalcazar M*, Merched A*
, Carr B, Oka K, Chen K-H, Pastore L, Beaudet A, Chan L. Long-term stable expression of human
apolipoprotein A-I mediated by helper-dependent adenovirus gene transfer inhibits atherosclerosis progression and remodels
atherosclerotic plaques in a mouse model of familial hypercholesterolemia (* equal contribution).
Circulation 107:2726-2732.

Oka K, Pastore L, Kim I-H, Merched A, Nomura S, Lee HJ, Merched-Sauvage M, Arden-Riley C, Lee B, Finegold M, Beaudet A, Chan L.
Long-term reversal of hypercholesterolemia and prevention of atherosclerosis development in LDL receptor-deficient mice by transfer
of the VLDL receptor gene in vivo using helper-dependent adenoviral vector.
Circulation. 103(9):1274-1281.

Merched A, Xia Y, Visvikis S, Serot JM, Siest G (2000). Decreases in high density lipoprotein- cholesterol and serum apolipoprotein AI
concentrations are highly correlated with the severity of Alzheimer's disease.
Neurobiology of Aging; 2000;21(1):27-30.

Dergunov AD, Smirnova EA, Merched A, Visvikis S, Siest G (2000). Conformation of apolipoprotein E both in free and in lipid-bound
form may determine the avidity of triglyceride-rich lipoproteins to the LDL receptor: structural and kinetic study.
Biochimica Biophysica
Acta
/Molecular and Cell Biology of Lipids;1484(1):14-28.

Dergunov AD, Smirnova EA, Merched A, Visvikis S, Siest G (2000). Structural peculiarities of the binding of very low density lipoproteins
and low density lipoproteins to the LDL receptor in hypertriglyceridemia: role of apolipoprotein E.
Biochimica Biophysica
Acta
/Molecular and Cell Biology of Lipids;1484(1):29-40.

Merched A, Serot JM, Visvikis S, Faure G and Siest G (1998). Apolipoprotein E, Transthyretin and Actin in the CSF of Alzheimer’s
Patients: Relation with the Senile Plaques and Cytoskeleton Biochemistry.
FEBS Letters; 425(2):225-228.

Terrisse L., Poirier J, Bertrand Ph, Merched A, Siest G, Ross M, and Rassart E (1998). Increased levels of ApoD in cerebrospinal fluid
and hippocampus of Alzheimer's patients.
Journal of Neurochemistry; 71(4):1643-1650.

Merched A, Xia Y, Papadopoulou A, Siest G and Visvikis S. (1998 ) Apolipoprotein AIV codon 360 mutation increases with aging and is
not associated with Alzheimer’s disease.
Neuroscience Letters; 242(2):117-119.

Merched A., Blain H, Visvikis S., Herbeth B, Jeandel C, and Siest G. (1997) Cerebrospinal fluid Apolipoprotein E is increased in late
onset Alzheimer’s disease.
Journal of the Neurological Science; 145: 33-39.

Blain H, Merched A, Visvikis S, Siest G, and Jeandel C (1997) Apolipoprotein E level in cerebrospinal fluid increases with aging.

Journal of the American Geriatric Society;
45(12):1536.

Book chapters
Merched A and Chan L. (2010). Atherosclerosis in experimental animal models. In: Serhan CN, Ward PA, Gilroy DW, eds.
Fundamentals of Inflammation. Cambridge University Press; 426-431.

Bohnet K., Schlenck A., Merched A., Siest G., Visvikis S. (1997) Apolipoprotein R136C. A rare variant of human apolipoprotein E
discovered during the STANISLAS Cohort study In: Biologie prospective. Comptes Rendus du 9° Colloque de Pont à Mousson, Ed.
Galteau MM, Delwaide P, Siest G, Henny J. John Libbey Eurotext, Paris, pp 167-170.

Merched A, L. Terrisse, P. Bertrand, J. Poirier, S. Visvikis, G. Siest, R. Milne, E. Rassart (1998) Les apolipoprotéines D et E dans le
système nerveux central des patients Alzheimeriens. In: Actualités sur la Maladie d’Alzheimer et les Syndromes Apparentés Ed. Gelly-
Nargeot MC, Ritchi K, Touchon J. SOLAL, Marseille, France, pp 57-63.

Merched A, S. Visvikis, J.-M. Serot, L. Terrisse, E. Rassart, G. Siest (1998). Génétique de l’apolipoprotéine E et Association avec la
transthyrétine, l’apolipoproteine D et l’actine dans la maladie d’Alzheimer. In: Actualités sur la Maladie d’Alzheimer et les Syndromes
Apparentés Ed. Gelly-Nargeot MC, Ritchi K, Touchon J. SOLAL, Marseille, France, pp 65-72.

Blain H, Merched A, Visvikis S, Herbeth B, Siest G and Jeandel C (1998). La concentration de l’apolipoprotéine E dans le liquide
céphalorchidien est augmentée dans le maladie d’Alzheimer. In: Actualités sur la Maladie d’Alzheimer et les Syndromes Apparentés
Ed. Gelly-Nargeot MC, Ritchi K, Touchon J. SOLAL, Marseille, France, pp 33-42.
Prof. Aksam J. Merched's Scientific Publications
See latest publications via pubmed
Professor Merched
Research interests

Inflammation, innate immunity, autoimmunity, immunotherapy, phagocytosis,
lipid biochemistry, biomarkers, animal models, molecular nutrition,
nutrigenetics of essential fatty acids, lipid mediators, Alzheimer's disease,
cardiovascular diseases, cancer.