Lau PP, Li L, Merched AJ, Zhang AL, Ko KWS and Chan L. (2006). Nicotine Induces Proinflammatory Responses in
Macrophages and the Aorta Leading to Acceleration of Atherosclerosis in LDLR-/- Mice. Arteriosclerosis Thrombosis and
Vascular Biology. 26(1):143-149
Merched A and Chan L. (2004). Absence of p21(Waf1/Cip1/Sdi1) Modulates Macrophage Differentiation and Inflammatory
Response and Protects Against Atherosclerosis. Circulation. 110(25):3830-3841.
Nomura S, Merched A, Nour E, Dieker C, Oka K and Chan L. (2004). LDL Receptor gene therapy with helper-dependent
adenovirus produces long-term protection in a mouse model of familial hypercholesterolemia. Gene Therapy. 11(20):
1540-1548.
Serhan CN, Jain A, Marleau S, Clish C, Kantarci A, Behbehani B, Colgan SP, Stahl GL, Merched A, Petasis NA, Chan L,
and Van Dyke TE. (2003).Reduced inflammation and tissue damage in transgenic rabbits overexpressiong 15-
lipoxygenase and endogenous anti-inflammatory lipid mediators. Journal of Immunology. 171: 6856-6865.
Merched A, Williams L and Chan L. (2003). Macrophage-specific p53 expression plays a crucial role in atherosclerosis
development and plaque remodeling. Arteriosclerosis Thrombosis and Vascular Biology. 23(9):1608-14..
Belalcazar M*, Merched A*, Carr B, Oka K, Chen K-H, Pastore L, Beaudet A, Chan L. Long-term stable expression of
human apolipoprotein A-I mediated by helper-dependent adenovirus gene transfer inhibits atherosclerosis progression
and remodels atherosclerotic plaques in a mouse model of familial hypercholesterolemia (* equal contribution).
Circulation 107:2726-2732.
Oka K, Pastore L, Kim I-H, Merched A, Nomura S, Lee HJ, Merched-Sauvage M, Arden-Riley C, Lee B, Finegold M, Beaudet
A, Chan L. Long-term reversal of hypercholesterolemia and prevention of atherosclerosis development in LDL receptor-
deficient mice by transfer of the VLDL receptor gene in vivo using helper-dependent adenoviral vector. Circulation. 103(9):
1274-1281.
Merched A, Xia Y, Visvikis S, Serot JM, Siest G (2000). Decreases in high density lipoprotein- cholesterol and serum
apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer's disease. Neurobiology of Aging; 2000;
21(1):27-30. [IF=5.5]
Dergunov AD, Smirnova EA, Merched A, Visvikis S, Siest G (2000). Conformation of apolipoprotein E both in free and in
lipid-bound form may determine the avidity of triglyceride-rich lipoproteins to the LDL receptor: structural and kinetic study.
Biochimica Biophysica Acta/Molecular and Cell Biology of Lipids;1484(1):14-28. [IF=5]
Dergunov AD, Smirnova EA, Merched A, Visvikis S, Siest G (2000). Structural peculiarities of the binding of very low density
lipoproteins and low density lipoproteins to the LDL receptor in hypertriglyceridemia: role of apolipoprotein E. Biochimica
Biophysica Acta/Molecular and Cell Biology of Lipids;1484(1):29-40. [IF=5]
Merched A, Serot JM, Visvikis S, Faure G and Siest G (1998). Apolipoprotein E, Transthyretin and Actin in the CSF of
Alzheimer’s Patients: Relation with the Senile Plaques and Cytoskeleton Biochemistry. FEBS Letters; 425(2):225-228.
[IF=3.8]
Terrisse L., Poirier J, Bertrand Ph, Merched A, Siest G, Ross M, and Rassart E (1998). Increased levels of ApoD in
cerebrospinal fluid and hippocampus of Alzheimer's patients. Journal of Neurochemistry; 71(4):1643-1650. [IF=4.8]
Merched A, Xia Y, Papadopoulou A, Siest G and Visvikis S. (1998 ) Apolipoprotein AIV codon 360 mutation increases with
aging and is not associated with Alzheimer’s disease. Neuroscience Letters; 242(2):117-119. [IF=2]
Merched A., Blain H, Visvikis S., Herbeth B, Jeandel C, and Siest G. (1997) Cerebrospinal fluid Apolipoprotein E is
increased in late onset Alzheimer’s disease. Journal of the Neurological Science; 145: 33-39. [IF=2.4]
Blain H, Merched A, Visvikis S, Siest G, and Jeandel C (1997) Apolipoprotein E level in cerebrospinal fluid increases with
aging. Journal of the American Geriatric Society; 45(12):1536. [IF=3.4]
Book chapters
Bohnet K., Schlenck A., Merched A., Siest G., Visvikis S. (1997) Apolipoprotein R136C. A rare variant of human
apolipoprotein E discovered during the STANISLAS Cohort study In: Biologie prospective. Comptes Rendus du 9°
Colloque de Pont à Mousson, Ed. Galteau MM, Delwaide P, Siest G, Henny J. John Libbey Eurotext, Paris, pp 167-170.
Merched A, L. Terrisse, P. Bertrand, J. Poirier, S. Visvikis, G. Siest, R. Milne, E. Rassart (1998) Les apolipoprotéines D et E
dans le système nerveux central des patients Alzheimeriens. In: Actualités sur la Maladie d’Alzheimer et les Syndromes
Apparentés Ed. Gelly-Nargeot MC, Ritchi K, Touchon J. SOLAL, Marseille, France, pp 57-63.
Merched A, S. Visvikis, J.-M. Serot, L. Terrisse, E. Rassart, G. Siest (1998). Génétique de l’apolipoprotéine E et Association
avec la transthyrétine, l’apolipoproteine D et l’actine dans la maladie d’Alzheimer. In: Actualités sur la Maladie d’Alzheimer
et les Syndromes Apparentés Ed. Gelly-Nargeot MC, Ritchi K, Touchon J. SOLAL, Marseille, France, pp 65-72.
Blain H, Merched A, Visvikis S, Herbeth B, Siest G and Jeandel C (1998). La concentration de l’apolipoprotéine E dans le
liquide céphalorchidien est augmentée dans le maladie d’Alzheimer. In: Actualités sur la Maladie d’Alzheimer et les
Syndromes Apparentés Ed. Gelly-Nargeot MC, Ritchi K, Touchon J. SOLAL, Marseille, France, pp 33-42.
Communications during last 3 years
Merched A, Ko K, Tollefson K, Gotlinger K, Serhan CN, and Lawrence Chan L (coming). Role of lipoxin A4 and
inflammatory cytokines in the 12/15-lipoxygenase mediated modulation of atherosclerosis. Oral. American Heart
Association: 77th Scientific Sessions, November 13-16, 2005 Dallas, TX, USA.
Merched A, Tollefson K and Chan L (coming). Dynamic involvement of b2 integrins in the initiation and progression of
atherosclerosis in the LDLR knockout mouse model. Poster. American Heart Association: 77th Scientific Sessions,
November 13-16, 2005 Dallas, TX, USA.
Merched A, Tollefson K, Chan L The dynamic involvement of b2 integrins in the initiation and the progression of
atherosclerosis in the LDLR knockout mouse model. Poster. 2eme Congrès Annuel NSFA - June 9-11, 2005, Biarritz,
France.
Merched A, Tollefson K, Chan L. Absence of p21Waf1/Cip1/Sdi1 Modulates Macrophage Differentiation and Inflammatory
Response and Protects Against Atherosclerosis. Oral. American Heart Association: 76nd Scientific Sessions, November 7-
10, 2004, New Orleans, LA, USA.
Merched A and Chan L. Role of p21 (waf1) in the development of atherosclerotic lesions. Oral. 1er Congrès Annuel NSFA -
June 10-12, 2004, Biarritz, France.
Ko KWS, Merched AJ, Chan L. Macrophage-Specific Transgenic Overexpression of 15-Lipoxygenase Attenuates
Atherosclerosis in ApoE-Deficient Mice. Poster. 5th Annual Conference on Arteriosclerosis Thrombosis and Vascular
Biology Meeting May 6-8, 2004, San Francisco, CA, USA.
Merched A, Williams L and Chan L. p21 deficiency protects against atherosclerosis in apolipoprotein E knockout mice.
Poster. American Heart Association: 76nd Scientific Sessions, November 2003, Orlando, FL, USA.
Oka K, Nomura S, Merched A, Pastore L, Beaudet A & Chan L. In-vivo LDL Receptor Gene Therapy is Highly Effective in
Reversing Hypercholesterolemia in a Mouse Model of Familial Hypercholesterolemia. Oral. The 6th Annual Meeting of the
American Society of Gene Therapy. June 4-8, 2003, Washington, DC USA.
Oka K, L. Belalcazar M, Merched A, Pastore L, Beaudet A, Chan L. Long-Term Stable Expression of Human Apolipoprotein
A-I Mediated by Helper-Dependent Adenovirus Gene Transfer Inhibits Atherosclerosis Progression and Remodels
Atherosclerotic Plaques in a Mouse Model of Familial Hypercholesterolemia. Oral. The 5th Annual Meeting of the American
Society of Gene Therapy. June 5-9, 2002, Boston, MA, USA.
