Communications presented in scientific meetings and workshops
(France, Italy, Germany, Belgium, USA, Canada, Singapor,...).

During the last 5 years:

Merched A, Ko K, Tollefson K, Gotlinger K, Serhan CN, and Lawrence Chan L . Role of lipoxin A4 and inflammatory cytokines
in the 12/15-lipoxygenase mediated modulation of atherosclerosis. Oral. American Heart Association: 77th Scientific
Sessions,
November 13-16, 2005 Dallas, TX, USA.

Merched A, Tollefson K and Chan L . Dynamic involvement of beta 2 integrins in the initiation and progression of
atherosclerosis in the LDLR knockout mouse model. Poster. American Heart Association: 77th Scientific Sessions,
November 13-16, 2005 Dallas, TX, USA

Merched A, Tollefson K, Chan L The dynamic involvement of b2 integrins in the initiation and the progression of
atherosclerosis in the LDLR knockout mouse model. Poster. 2eme Congrès Annuel NSFA -
June 9-1, 2005, Biarritz ,
France
.

Merched A, Tollefson K, Chan L. Absence of p21Waf1/Cip1/Sdi1 Modulates Macrophage Differentiation and Inflammatory
Response and Protects Against Atherosclerosis. Oral. American Heart Association: 76nd Scientific Sessions,
November
7-10, 2004 New Orleans, LA, USA
.
in pictures....
Council on  Basic Cardiovascular Sciences dinner and
business meeting Nov 2005
Talk at AHA meeting Dallas 2005
NSFA 2005, Biarritz
Basque Barbecue NSFA 2005, Biarritz
AHA meeting
New Orleans,
Louisiana, 2004
During NSFA meeting (Biarritz, France, 2003)
Biarritz by night  (France, 2004)
AHA meeting Orlando, Florida, 2003
Merched A and Chan L. Role of p21 (waf1) in the development of atherosclerotic lesions.  Oral. 1er Congrès Annuel
NSFA -
10-12 juin 2004, Biarritz , France.

Ko KWS,  Merched AJ, Chan L. Macrophage-Specific Transgenic Overexpression of 15-Lipoxygenase Attenuates
Atherosclerosis in ApoE-Deficient Mice.  Poster. 5th Annual Conference on Arteriosclerosis Thrombosis and Vascular
Biology Meeting
May 6-8, 2004, San Francisco, CA,  USA.

Merched A, Williams L and Chan L. p21 deficiency protects against atherosclerosis in apolipoprotein E knockout mice.
Poster.  American Heart Association: 76th Scientific Sessions,
November 2003, Orlando, FL, USA.

Kazuhiro O, Nomura S, Merched A, Pastore L, Beaudet A, Chan L. In-Vivo LDL Receptor Gene Therapy Is Highly effective
in Reversing Hypercholesterolemia in a Mouse Model of Familial Hypercholesterolemia. Poster. The 5th Annual Meeting
of the American Society of Gene Therapy.
June 4-8, 2003 in Washington, DC USA.

Oka K, L. Belalcazar M, Merched A, Pastore L, Beaudet A, Chan L. Long-Term Stable Expression of Human
Apolipoprotein A-I Mediated by Helper-Dependent Adenovirus Gene Transfer Inhibits Atherosclerosis Progression and
Remodels Atherosclerotic Plaques in a Mouse Model of Familial Hypercholesterolemia. Oral. The 5th Annual Meeting of
the American Society of Gene Therapy. June 5-9,
2002, Boston, MA USA.

Merched A, Williams L and Chan L. Macrophage-specific p53 expression plays a crucial role in atherosclerosis
development. Poster. Department of Medicine Annual Research Symposium April 4,
2002, BCM Houston, TX, USA.

Nomura N, Oka K, Merched A, Pastore P, Beaudet A, Chan L. Long-Term Reversal of Hypercholesterolemia by a Single
Injection of a Helper-Dependent Adenovirus Expressing LDL Receptor Markedly Inhibits Aortic Atherosclerosis
Progression in a Mouse Model of Familial Hypercholesterolemia. Oral. American Heart Association: 74th Scientific
Sessions, November
2001, New Orleans, LO, USA.

Belalcazar M, Merched A, Carr B, Antanova E, Chen K-H, Oka K, Lucio P, Beaudet A, Chan L. Somatic Gene Therapy for
Long-Term Stable Correction of Genetic HDL Deficiency and Atherosclerotic Disease in Mice Using a Novel Nontoxic
Adenoviral Human ApoA-I Vector. Oral. American Heart Association: 73d Scientific Sessions, November
2000, New
Orleans, LO, USA
.

Pastore L., Oka K., Belalcazar M., Kim I.-H., Merched A., Cela R., Lee B., Beaudet A.L., Chan L.. Helper-dependent
adenoviral vectors for gene therapy of atherosclerosis. Oral. The American Society of Human Genetics Fiftieth Annual
Meeting October
2000, Philadelphia PA USA.

Dergunov A.D., E. A. Smirnova, A. Merched, S. Visvikis, G. Siest Binding of triglyceride-rich lipoproteins to the LDL receptor
in hypertriglyceridemia: role of apolipoprotein E. Poster. High Density Lipoproteins And Atherosclerosis IAS Satellite
Symposium, July 1-3, 2000, Helsinki, Finland.

Chan L, K Oka, M Belalcazar, I-H Kim, A. Merched, K-H Chen, L Pastore, B Lee, A Beaudet. Novel Approaches to the
Treatment of Dyslipidemia by Liver-directed Gene. Oral. The Third Annual Meeting of the American Society of Gene
Therapy, May 31 - June 4,
2000 Denver, Colorado, USA.



More communications

Oka K, Kim I-H, Merched A, Pastore L, Beaudet A, Chan L. Long-Term Expression of VLDL Receptor by a Helper-
Dependent Adenoviral Vector Reduces Atherosclerosis in a Mouse Model of Familial Hypercholesterolemia. Oral.
American Heart Association: 72nd Scientific Sessions, 8 Novembre
1999, Atlanta, GA, USA.

Guevara NV, Merched A, Kim HS, Antonova EI, Chan L. New insights into the role of p53 in atherosclerosis. Oral. II
Minicolloqium Biologie Perspective, 22-23 March 1
999, Nancy, France.

Terrisse L, Marcoux-Legault K, Merched A, Sirois J, Poirier J, Siest G, Milne R, Rassart E. Niveaux élevés
d'apolipoprotéine D dans le liquide céphalo-rachidien et dans l'hippocampe de patients atteints de la maladie
d'Alzheimer. Génétique Humaine au Québec May 21,
1998, Quebec, Canada.

Merched A, Xia Y, Papadopoulou A, Siest G and Visvikis S. Apolipoprotein AIV codon 360 mutation increases with aging
and is not associated with Alzheimer’s disease. Poster. Human Genomics. The basis of the Medicine of Tomorrow, 15-
18 March,
1998, Singapour.

Jeandel C, Blain H, Merched A, Visvikis S, and Siest G. La concentration dans le LCR de l’apolipoprotéine E augmentée
avec l’avancée en âge. IVème Réunion Francophones sur la Maladie d’Alzheimer et les Syndromes Apparentées. Poster.
2-4 octobre
1997, Marseille, France.

Jeandel C, Blain H, Merched A, Visvikis S, and Siest G. Concentration dans le LCR de l’apolipoprotéine E dans le
maladie d’Alzheimer. IVème Réunion Francophones sur la Maladie d’Alzheimer et les Syndromes Apparentées. Oral. 2-4
octobre
1997, Marseille, France.

Merched A, L. Terrisse, P. Bertrand, J. Poirier, S. Visvikis, G. Siest, R. Milne, E. Rassart Les apolipoprotéines D et E dans
le système nerveux central des patients Alzheimeriens. IVème Réunion Francophones sur la Maladie d’Alzheimer et les
Syndromes Apparentées. Poster. 2-4 octobre
1997, Marseille, France.

Merched A, S. Visvikis, J.-M. Serot, L. Terrisse, E. Rassart, G. Siest. Génétique de l’apolipoprotéine E et Association avec
la transthyrétine, l’apolipoproteine D et l’actine dans la maladie d’Alzheimer. IVème Réunion Francophones sur la
Maladie d’Alzheimer et les Syndromes Apparentées. Oral. 2-4 octobre
1997, Marseille, France.

Merched A, Blain U, Visvikis S, Jeandel C and Siest G. Le vieillissement et la maladie d’Alzheimer affectent la
concentration de l’apolipoprotéine E dans le liquide céphalorachidien. Oral. IIIème Réunion de la Société de Biologie du
Vieillissement. 20 juin
1997, Paris, France.

Merched A, Visvikis S, Blain U, Jeandel C and Siest G Apolipoprotein E in cerebrospinal fluid increases with aging,
Alzheimer’s disease and some neurodegenerative pathologies. Poster. 68th Meeting of the European Atherosclerosis
Society. 8-10 mai
1997, Brugge, Belgium.


Dr. Aksam J. Merched's Scientific Communications